Updating p300 an integrative theory of p3a and p3b

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Comorbid patients showed both anxiety-related and depression-related activity.

A superimposition effect of depression and anxiety was identified with (1) aggravated hypo-function of the right-lateralized dorsal attention and salience networks and (2) complicated anxiety-related hyper-function of the left-lateralized ventral attention and salience networks..

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In addition, subjects completed blocks of stimuli under instruction to count the number of loud tones, count the number of soft tones, or ignore the tones and quietly read.

is a component of time-locked (EEG) signals known as event-related potentials (ERP).

The P3a is a positive-going scalp-recorded brain potential that has a maximum amplitude over frontal/central electrode sites with a peak latency falling in the range of 250–280 ms.

estless legs syndrome may be a condition of impaired CNS dopamine function.

Dopamine deficiency is associated with bradykinesia and impaired attention (e.g., Parkinson's disease and attention deficit disorder), and dopamine restoration or excess (e.g., treatment of patients with Parkinson's disease with L-3,4-dihydroxyphenlyalanine [L-dopa] and of patients with attention deficit disorder with amphetamine) is associated with normal or excessive movement and with improved attention.

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